What are the basic principles of genetics

Human genetics

Biological-medical focus subject

Coordinator: Dr. Thorsten Schmidt

Institute for Human Genetics,
Medical Genetics Department, Tel .: 29-72286
email: thorsten.schmidtspam [email protected]

Courses offered

1 | Lecture "Human Genetics I" (Genetic Variability of Human Populations)

  • Is not identical to 2).
  • Lecturer: J. Tomiuk
  • Only in the winter semester
  • 2 SWS
  • Accompanying seminar: "Exercises in Human Genetics I" (see below 9)
  • Examination for the lecture: Exam

2 | Lecture "Applied Human Genetics Part I - Clinical Genetics"

Presentation of important basic principles and methods of human genetics

  • Lecturers: O. Riess, U. Mau-Holzmann, A. Dufke, R. Hering, A. Riess, U. Grasshoff, H. Enders
  • Every semester one lecture block (7 two-hour lectures)
  • 1 SWS
  • Accompanying seminar: None
  • Examination for the lecture: No
  • Order of lectures: Attending lecture I before lecture II (see 3 below) is recommended.

3 | Lecture "Applied Human Genetics Part II"

The most important genetic diseases are picked up and analyzed in an organ-oriented manner.

  • Lecturers: O. Riess, U. Mau-Holzmann, A. Dufke, R. Hering, A. Riess, U. Grasshoff, H. Enders
  • Every semester one lecture block (5 two-hour lectures)
  • 1 SWS
  • Accompanying seminar: None
  • Examination for the lecture: No
  • Order of lectures: Attending lecture I (see above 2) before lecture II is recommended.

Content

Special problem areas of human genetics are addressed in order to introduce the work areas and methods of this interdisciplinary field (medicine / biology). Using human genetic model cases, the following topics are discussed:

  • Mutation and genetic variability
  • Multifactorial diseases
  • Identification of genes using linkage analyzes
  • Oncogenesis and the genetic control of growth and cell differentiation
  • Basics of neurogenetics
  • Animal model systems for characterizing genes

4 | Lecture "Basics and Techniques of Molecular Genetics"

Lecture prepares students for practical work in molecular genetics.

  • Lecturers: M. Bonin, P. Bauer, T. Schmidt
  • Every semester
  • 1 SWS
  • Accompanying seminar: None
  • Examination for the lecture: Exam

Content

Structure and function of DNA, RNA and protein. Techniques of DNA, RNA and protein analysis, use of the internet in genetic research.

5a | Lecture "Gene Regulation"

Forms of eukaryotic expression regulation

  • Lecturer: M. Bonin
  • Only in the winter semester
  • 1 SWS
  • Accompanying seminar: None
  • Examination for the lecture: Oral exam

5b | Lecture "Microarrays from A-Z"

  • Lecturer: M. Bonin
  • Only in summer semester
  • 1 SWS
  • Accompanying seminar: None
  • Examination for the lecture: Oral exam

6 | Lecture "Human Genetics II" (Current Topics in Human Genetics)

  • Is not identical to 3).
  • Lecturers: N. Blin, C. Pusch, J. Tomiuk, O. Riess
  • Only in summer semester
  • 1 SWS
  • Accompanying seminar: None
  • Examination for the lecture: No

7 | "Human Genetics Seminar, Part I" (Aspects of Clinical Genetics)

The seminar is clinically oriented, but is aimed at natural scientists. It also includes the preparation of a seminar presentation.

  • Lecturers: P. Bauer, M. Bonin, A. Dufke, K. Grundmann, R. Hering, U. Mau-Holzmann, O. Rieß, T. Schmidt, S. Singer, M. Walter, B. Wissinger, D. Berg, T. Ott
  • Only in the winter semester
  • 2 SWS
  • Exam for the seminar: No

8 | Seminar "Human Genetics Seminar, Part II" (Evolutionary Genetics)

The seminar deals with the evolution of humans and also includes the preparation of a seminar lecture.

  • Lecturers: N. Blin, C. Pusch, J. Tomiuk
  • Only in summer semester
  • 2 SWS
  • Examination for the seminar: No

Content

The following topics related to hominid evolution are discussed: molecular anthropology, primatology and evolutionary genetics, population genetics and speciation processes. Methodological approaches, their advantages and problems.

9 | Seminar "Exercises in Human Genetics I"

  • Lecturer: J. Tomiuk
  • Only in the winter semester
  • 2 SWS
  • Accompanying seminar to the lecture "Human Genetics I (Genetic Variability of Human Populations)"
  • Examination for the seminar: Exam

10 | Internship "Human Cytogenetics" (Chromosome Internship)

This event teaches the basics and techniques of cytogenetic chromosome analysis.

  • Lecturers: U. Grasshoff, A. Riess, S. Singer
  • Every semester
  • 2 SWS
  • Internship seminar: None
  • Examination for internship: Exam

11a | Internship "Specialty Molecular Genetics (+ Biocomputing)"

In the course, various methods and techniques for the purification, enrichment and analysis of human DNA, especially in connection with the detection of mutations for hereditary diseases, are presented and applied. This includes isolation of DNA from blood, PCR amplification, DNA sequencing, RFLP analysis, dHPLC separation, and SNP genotyping methods.

  • Lecturers: N. Blin, C. Pusch
  • Every semester
  • Alternative to 11b)
  • Block course (1 week full day)
  • 1 SWS
  • Internship seminar: None
  • Examination for internship: No

11b | Internship "Molecular Genetics Special Course (Methods of Molecular Genetic DNA Analysis)"

  • Lecturers: B. Wissinger, S. Kohl, N. Weißschuh
  • Only in the winter semester
  • Alternative to 11a)
  • Block course (1 week full day)
  • 1 SWS
  • Internship seminar: None
  • Examination for internship: No

The required 14 SWS are achieved through a combination
i) internships 10) + 11a) or 11b) [together 3 SWS],
ii) of lectures 1); 2); 3); 4) [together 5 SWS],
iii) two of the three lectures 5a), 5b), 6) [together 2 SWS],
iv) as well as seminars 7) and 8) [together 4 SWS].