What is Dermatophytic Onychomycosis Market Research
Antifungal drugs in the treatment of onychomycosis
Onychomycosis accounts for up to 30% of all superficial skin infections and makes up about half of all nail abnormalities; Around 5% of the world's population are affected
The prevalence of onychomycosis is determined by age, social class, occupation, climate, living environment and frequency of travel. Despite general dermatological presentation, the exact prevalence of onychomycosis is largely unknown.
Toenails are more often affected than fingernails due to the slower growth rate of the toenails than the former, decreased blood supply and usual containment in dark, humid environments Infection is more common in adult men (especially the elderly> 60 years of age), diabetics, immunocompromised people (e.g. HIV- positive), people with peripheral vascular (arterial) disease, previous Tineapedis infection, a history of nail trauma, or those with a family history of onychomycosis dermatophytes, whether pathogenic or saprophytes are the most common causative nail invaders, dermatophytic onychomycosis can be divided into four main clinical types based on their present clinical characteristics; Distal and lateral subungual onychomycosis (DLSO), proximal subungual onychomycosis (PSO), white superficial onychomycosis (WSO) and total dystrophic onychomycosis (TDO), including distal and lateral subungual onychomycosis (DLSO), is the most common form.
Clinical diagnosis by physical examination alone can be just as imprecise as many non-infectious conditions that mimic onychomycosis, such as lichen planus, psoriasis, must be ruled out. Various laboratory techniques have been used to accurately diagnose onychomycosis, with microscopy through KOH and fungal culture being the most commonly used. The histopathology of nail sections can be used to diagnose onychomycosis with periodic acid-Schiff (PAS). Coloring that allows for easy visualization of fungal hyphae. Digital dermoscopy, also called onychoscopy, is a simple and quick procedure that allows the differential diagnosis of onychomycosis due to the most common nail dystrophies.
Dystrophic nails can be a social obstruction that creates significant embarrassment in the patient's self-esteem. In addition, thickened nails can be painful, interfere with the function of the nail unit and cause discomfort when walking, standing and exercising.
Although it initially presents itself as a cosmetic problem, it can ultimately lead to permanent problems with disfigurement of the nails and act as a source of other fungal infections. Because of this, the specific Significant Effects Questionnaire was designed and validated to assess the quality of life in patients with onychomycosis
Treatment is chosen depending on the type of nail invasion, the type of fungus and the number of nails affected. Oral treatments are often limited by drug interactions, although topical antifungal drugs are less effective. Surgery or nail debridement is another invasive treatment option in limited resistant cases.
The use of griseofulvin and ketoconazole is problematic as it typically has high relapse rates of 50-85%. In addition, treatment must be continued over a long period with risk of systemic side effects.
Fluconazole, itraconazole and terbinafine are relatively safe antifungal agents widely used with improved treatment success and lead to a mycological cure in more than 90% of cases of fingernail infections and in about 80% of toenail infections
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