How to dilute sodium hypochlorite NaClO

Sodium hypochlorite solutions

"Sodium hypochlorite in a concentration between 0.5% and 5% is considered the first choice rinsing solution for root canal treatment," writes the German Society for Dentistry, Oral and Maxillofacial Medicine (DGZMK) in a joint statement with the German Society for Tooth Preservation ( DGZ) [1].

Rinsing with sodium hypochlorite not only removes dentin chips, but also kills bacteria. It also dissolves and removes remnants of pulp tissue. Sodium hypochlorite is therefore used in dentistry for root canal irrigation during root treatment.

Solutions with different sodium hypochlorite concentrations, usually between 0.5% and 3%, are used. The antimicrobial effect and the dissolution of the pulp tissue increase with increasing concentration. The sodium hypochlorite solution 5%, which is occasionally required, is, like all higher concentrated sodium hypochlorite solutions, relatively unstable (cold storage necessary) and poorly tolerated [2; 3].


Sodium hypochlorite solution is available on the market with various chlorine contents. However, the 12.5% ​​solution is unstable and loses over half of its chlorine content within 6 months (from 15.0% to 6.0% at room temperature). The dilution of the concentrated solution to form a dental product is possible for the pharmacist, but not economical; because before it is diluted, the actual chlorine content of the concentrated solution must be determined by titration. This additional effort can hardly be passed on to the customer in terms of price - but we can take over this additional effort for you.

Hedinger already offers diluted 1% and 3% sodium hypochlorite solutions attractively priced as active pharmaceutical ingredients. They are available through pharmacies. The solutions have the advantage that they are stable for 18 months (1% solution) or 10 months (3% solution) if unopened. A pharmaceutical active ingredient is a certified active ingredient that can be further used in the formulation within the framework of the regulations of the pharmacy operating regulations.

Hedinger produces the 1% and 3% sodium hypochlorite solution in accordance with GMP in class D clean rooms. The 12.5% ​​solution has already been filtered, the diluted solutions are again filled into 250 ml and 500 ml bottles through a 0.2 µm filter. This manufacturing practice corresponds to the regulations of the EU-GMP Guide Part II for active pharmaceutical ingredients. In addition, Hedinger's quality control laboratory checks the quality according to the recognized rules of the German Medicines Codex (DAC). The solutions are therefore available with a test certificate: