What is used to cut fentanyl


Which transdermal opioid patch can be cut up with few side effects?

Dr. med. D.K. BUDI (specialist in general medicine, chiro / psychotherapy)
D-55411 Bingen
Conflict of Interest: none

Two opioids are currently also available as patches: fentanyl (DUROGESIC; a-t 1996; No. 9: 88-9) and buprenorphine (TRANSTEC; a-t 2002; 33: 4, 13).

The one that has been available for a long time Fentanyl TTS* consists of a gel-like drug reservoir and a membrane that ensures the controlled release of the active ingredient. Do not damage, split, or cut it as the opioid will be released in an uncontrolled manner.1

Buprenorphine is evenly distributed in TRANSTEC in a matrix, from which it is released proportionally to the area of ​​the skin that is covered. Cutting the patch once should not destroy this matrix, so that the active ingredient continues to be released in a controlled manner. The adhesive properties should also be retained.2 However, the information for healthcare professionals does not contain any information on whether the patches are divisible. There is also a lack of information about the structure.3 We neither find studies on the use of halved plasters in a database search (PubMed) nor do we receive them from the manufacturer on request. Due to a lack of documentation of benefits and safety as well as possible liability problems, we cannot recommend cutting this plaster either, -Red.